EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

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The Saturday Profile: Peng Liyuan, First Lady of China, Dimmed Her Star


Imaginechina, via Agence France-Presse — Getty Images


Peng Liyuan performing in Beijing in 2009.







BEIJING — Peng Liyuan, China’s most enduring pop-folk icon, is beloved for her glass-cracking soprano and her ability to take on such roles as a coquettish Tibetan yak herder, a lovelorn imperial courtesan, even a stiff-lipped major general — which in fact she is.




But as the nation begins to absorb the reality that its newly anointed top leader, Xi Jinping, is coming to office with a wife who happens to be a big-haired brassy diva known for her striking figure, palace watchers are daring to ask the question: has China’s Carla Bruni-Sarkozy moment finally arrived?


Ms. Peng, 49, certainly has what it takes to revolutionize China’s stodgy first lady paradigm, in which the spouses of top leaders are usually kept well out of sight or, at best, stand mute behind their husbands during state visits.


For more than two decades she was a lavishly costumed fixture on the nation’s must-see Chinese New Year variety show, often emerging from a blur of synchronized backup dancers to trill about the sacrifices of the People’s Liberation Army, which bestowed on her a civilian rank equivalent to major general. More recently, she has extended her celebrity to public service, comforting survivors of the Sichuan earthquake and gently scolding young people about the dangers of smoking and unprotected sex.


“Peng Liyuan could be an enormously positive thing for China, which really needs female role models,” said Hung Huang, publisher of a fashion magazine. “Just imagine if she turned out to be a first lady like Michelle Obama.”


But experts here agree that there is a major obstacle to Ms. Peng playing a more prominent role on the national stage: Chinese men. Despite Mao Zedong’s feel-good dictum that “women hold up half the sky,” they are barely visible in the inner sanctum of the granite-clad colossus on Tiananmen Square where Communist Party elders selected a new club of leaders.


While there was hopeful, unsubstantiated talk earlier this year that Liu Yandong, a woman, might be named to the seven-seat Politburo Standing Committee, the lineup revealed to the world on Thursday was an unrelieved row of dark suits, drab ties and black hair without a touch of gray. The party did throw out a bone: they added Sun Chunlan to the Politburo, which means the 25-member advisory committee now contains two women.


Chinese women — at least those who dare to speak out — are not pleased. “It’s unhealthy and unfair to have so few women within the Chinese political system,” said Guo Jianmei, director of the Women’s Legal Research and Service Center in Beijing, a nonprofit group. “It just reinforces the traditional cultural view that women are less capable than men.”


By all accounts, Chinese male chauvinism and the fear of the power-hungry vixen has been percolating for a few thousand years. Until the last century, women were kept uneducated and barred from the imperial bureaucracy. In times of famine, boys ate first. A lucky girl might have her growing feet bound so tightly she could barely walk by the time she was married off to the groom’s family as little more than chattel.



CCTV, via YouTube

Peng Liyuan starring in "When the National Anthem is Sung," a patriotic music video aired on CCTV in 2009.



Even today the gender imbalance — with 118 men for every 100 women — is a testament to Chinese favoritism toward boys, expressed through targeted abortions or abandoned baby girls. Many of the nation’s best schools give male students a leg up by requiring higher marks for women. The discriminatory scoring system, according to the Ministry of Education, is designed to “protect the interests of the nation.”


Ms. Guo said men dominate Chinese politics at the top because they keep the door firmly shut at the bottom. In a two-year study her institute recently completed, researchers in rural Heilongjiang Province found precious few female party officials at the village and county level. In questionnaires, she said, respondents did not mince words: men make better leaders.


“No wonder there are so few women at the top,” she said. “It’s a vicious cycle that’s only getting worse.”


Mia Li and Chang Lu contributed research.



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Cesar Millan Calls Suicide Attempt a 'Dark Moment'















11/17/2012 at 10:30 AM EST







Cesar Millan with dog Daddy


Meredith Jenks


After making a bombshell revelation about his attempted suicide in 2010, Cesar Millan is once again speaking out.

Millan, 43, who hosted National Geographic's Dog Whisperer with Cesar Millan until the series ended in September, opened up about his battle with depression – and the overdose that nearly took his life – for Cesar Millan: The Real Story, a documentary airing on Nat Geo Wild on Nov. 25.

"I have always been honest with my fans, which means being open about any struggles I have had along the way," he says in a statement. "It was important for me to explain all the aspects that have led to my new chapter. Although it was a dark moment for me, it showed me that I still needed to be here and I have a lot more to do."

Millan worked through his depression after the death of his dog, Daddy, and split from his wife, with the help of work and exercise. Now, two years later, he hopes that his story will help others in similar situations.

"It made me become aware of the pain I needed to deal with and to start the healing process," he says. "I am sharing this in my bio to help others who might feel like I did at that point."

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EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

Read More..

Girl, 15, forced into prostitution by family counselor




A San Bernardino family counselor responsible for providing services to children and families also coerced a 15-year-old girl into prostitution and sold sexual services on the Internet, the San Bernardino County district attorney's office said Thursday.


Daron Lamar Whitworth, 42, worked for EMQ FamiliesFirst, a nonprofit that provides social services, mental-health and foster care for young children and families in San Bernardino County, authorities said. He was arrested without incident Thursday and booked into Central Detention Center in San Bernardino. 


Police have issued arrest warrants for two alleged accomplices: Whitworth's uncle Jacory C. Williams, 30, and Charmaine Williams, 24, both of San Bernardino. Charmaine Williams is in Los Angeles County Jail for unrelated reasons. 

Whitworth faces 44 charges, including felony counts of human trafficking, pimping and pandering a minor under 16, and unlawful sexual intercourse with a minor, according to court records. 


Investigators from the Riverside County Sheriff's Department began to gather evidence in August after the arrest of a juvenile for street prostitution in Hemet. The investigation gradually revealed that most of the unlawful activity had taken place in San Bernardino County, according to the release. 


Anyone with additional information or who believes they have been a victim is encouraged to contact Sgt. John Sawyer with the Riverside County Sheriff's Department at (951) 544-7000.


ALSO:


Four 14-year-olds arrested in more than 400 acts of vandalism


‘Western Bandit’ wanted in 9 armed robberies, transgender slaying


Police arrrest Hawthorne man accused of raping woman he met online


-- Frank Shyong


twitter.com/frankshyong



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Tensions Escalate in Gaza Conflict



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John Duffy of 3C Interactive says he asks job candidates to describe what their first months on the job would be like, partly to “learn what their expectations are, and where they think we’re at.”



Find the best job in the New York metro area and beyond.










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American Idol Judges Are All Smiles in New Image






Only on People.com








11/16/2012 at 12:30 PM EST







From left: Randy Jackson, Mariah Carey, Ryan Seacrest, Nicki Minaj and Keith Urban


FOX


It's a wrap! American Idol's new judging panel just finished auditions for Season 12, and viewers will see which contestants earned golden tickets when the show debuts in exactly two months.

A Fox rep confirms that judges Mariah Carey, Nicki Minaj and Keith Urban, along with returning judge Randy Jackson and host Ryan Seacrest, completed the last round of auditions on Wednesday and Thursday aboard the Queen Mary, which is docked in Long Beach, Calif.

Next up for the judges – who are all smiles alongside Seacrest in an exclusive new Idol photo – is Hollywood Week, when they will whittle down the contestant pool to determine which singers will move on to the live shows.

Despite an on-set spat between Carey and Minaj during auditions in Charlotte, N.C., in early October, the judges have been getting along well during this latest round.

"Mariah and Nicki sat next to each other yesterday," an Idol source said Thursday. "There really is some great chemistry among all the judges."

The new panel has been working long hours, adds the source, but "they've found what they think is some seriously superstar talent out there."

The Long Beach set had its fill of special, expressive moments too, such as when an 8-year-old girl showed up dressed like Minaj – complete with a pink and blue wig – to support her auditioning aunt.

"Nicki told her she loved her color palette and talked to her about how important it is stay in school," says the source. "The little girl sang 'Starships' for Nicki, who let the girl and her brother sit on her lap for the audition. It was really cute."

The new season of Idol makes its debut over two nights, on Jan. 16 and 17.

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EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

Read More..

Irvine plans review of Great Park funds









Irvine leaders are planning a detailed review of the $200 million spent on what has been billed as the country's next great urban park, one that is supposed to rival New York's Central Park with a majestic man-made canyon, rivers, forests and botanical gardens.


Despite the spending, only a sliver of the park has been built, and most of the Marine base land remains fenced off. Park funds are expected to be exhausted next year.


With a new majority taking over the council next month, city leaders indicated that they want to take a closer look at the decade-long effort to build the municipal park.





PHOTOS: A not so 'Great Park'


"The three of us have been severe critics of the profligate spending at the park and because of that we want to know where every dime has gone and what we've received for it," said Jeff Lalloway, an incumbent council member. "I think that's a fair question."


Lalloway and his allies have been especially critical of the amount of money spent on planning, public relations and events at the Orange County Great Park rather than construction.


"I want to build the park," Lalloway said. "I'm not certain that the current council majority has been ever interested in doing that."


A Times analysis last month showed that less than a fifth of the money spent on the park was actually used for construction. Only about 200 of the promised 1,347 acres have been developed, and half of that has been leased for commercial farming. The runways of the former Marine base have yet to be pulled up, and some of the barracks remain.


The Times also found that nearly half the money contractors were paid was awarded without competitive bids and that a public relations firm was paid a $1.2-million annual retainer.


"My No. 1 suggestion is that the council authorize a forensic audit in the next year and look at where the dollars have gone," said Christina Shea, an incoming council member who previously served on the panel.


There have long been bitter feelings between the two Irvine council factions, and they have leaped to the forefront again.


Much of the new majority's anger is directed at Larry Agran, one of the park's strongest advocates and one of the city's most veteran political figures, who has long headed the liberal faction that has usually controlled city affairs.


"It's not Larry's private project, but the city's," Shea said. "We need to get it back on track. Is it worth $240 million? I don't think so."


Agran, who remains on the council after losing the race for mayor, declined to talk to The Times, other than insisting that there had been only one or two no-bid contracts.


Beth Krom, an Agran ally on the council, opposes an audit. "I would put it in the witch-hunt category," she said. "I'm not sure what they're looking for, what they're going to find. It's more about headlines than going forward."


She also criticized the new majority's attacks on the amount of money spent on planning. "In my world, you plan first and execute afterward," she said. "What we need now is not slash and burn. What we need is creativity. You can find money. You can't find vision."


Great Park was the object of one of Orange County's great political battles. County supervisors wanted an international airport on the decommissioned Marine base, but county voters decided in 2002 that they preferred a showcase park.


City leaders made a deal with a developer to build homes and businesses around the site that would provide taxes to pay for construction and operation of the park.


But the city now faces questions of how it is going to pay for the remaining park construction.


Developer FivePoint Communities Inc. put its plans on hold when the housing market crashed.


Then last spring, as part of its solution to California's budget deficit, the state grabbed the $1.4 billion in redevelopment funds that were earmarked for the park over the next 45 years.


FivePoint can build 4,894 homes. Early this year, the company offered to trade the rights to develop about 1 million square feet of commercial property for an additional 5,800 homes in a complicated deal that would bring the city about $200 million.


Lalloway, who has been half of Irvine's two-person negotiating committee, said they have not talked to FivePoint since May or June. "I personally have no idea where the deal is because in my opinion it's not moved since that time," he said.


jeff.gottlieb@latimes.com





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Attacks Resume After Israeli Assault Kills Hamas Leader





KIRYAT MALACHI, Israel — Israel and Hamas widened their increasingly deadly conflict over Gaza on Thursday, as a militant rocket killed three civilians in an apartment block in this small southern town. The deaths were likely to lead Israel to intensify its military offensive on Gaza, now in its second day of airstrikes.




In Gaza, the Palestinian death toll rose to 11 as Israel struck what the military described as medium- and long-range rocket and infrastructure sites and rocket-launching squads. The military said it had dispersed leaflets over Gaza warning residents to stay away from Hamas operatives and facilities, suggesting that more was to come.


The regional perils of the situation sharpened, meanwhile, as President Mohamed Morsi of Egypt warned on Thursday that his country stood by the Palestinians against what he termed Israeli aggression, echoing similar condemnation on Wednesday.


“The Egyptian people, the Egyptian leadership, the Egyptian government, and all of Egypt is standing with all its resources to stop this assault, to prevent the killing and the bloodshed of Palestinians,” Mr. Morsi said in nationally televised remarks before a crisis meeting of senior ministers. He also instructed his prime minister to lead a delegation to Gaza on Friday and said he had contacted President Obama to discuss strategies to “stop these acts and doings and the bloodshed and aggression.”


In language that reflected the upheaval in the political dynamics of the Middle East since the overthrow of Hosni Mubarak last year, Mr. Morsi said: “Israelis must realize that we don’t accept this aggression and it could only lead to instability in the region and has a major negative impact on stability and security in the region.”


The thrust of Mr. Morsi’s words seemed confined to diplomatic maneuvers, including calls to the United Nations secretary general, Ban Ki-moon, the head of the Arab League and President Obama.


The 120-nation Nonalignmed Movement, the biggest bloc at the United Nations, added its condemnation of the Gaza airstrikes in a statement released by Iran, the group’s rotating president and one of Israel’s most ardent foes. “Israel, the occupying power, is, once more, escalating its military campaign against the Palestinian people, particularly in the Gaza Strip,” the group’s coordinating bureau said in the statement. The group made no mention of the Palestinian rocket fire but condemned what it called “this act of aggression by the Israelis and their resort to force against the defenseless people” and demanded “decisive action by the U.N. Security Council.”


In his conversation with Mr. Obama, Mr. Morsi said, he “clarified Egypt’s role and Egypt’s position; our care for the relations with the United States of America and the world; and at the same time our complete rejection of this assault and our rejection of these actions, of the bloodshed, and of the siege on Palestinians and their suffering.”


Mr. Obama had agreed to speak with Israeli leaders, Mr. Morsi said.


The Thursday’ deaths in Kiryat Malachi were the first casualties on the Israeli side since Israel launched its assault on Gaza, the most ferocious in four years, in response to persistent Palestinian rocket fire.


Southern Israel has been struck by more than 750 rockets fired from Gaza this year that have hit homes and caused injuries. On Thursday, a rocket smashed into the top floor of an apartment building in Kiryat Malachi, about 15 miles north of Gaza. Two men and one woman were killed, according to witnesses at the scene. A baby was among the injured and several Israelis were hospitalized with shrapnel wounds after rockets hit other southern cities and towns, they said.The apartment house was close to a field in a blue-collar neighborhood and the rocket tore open top-floor apartments, leaving twisted metal window frames and bloodstains.


Nava Chayoun, 40, who lives on the second floor, said her husband, Yitzhak, ran up the stairs immediately after the rocket struck and saw the body of a woman on the floor. He rescued two children from the same apartment and afterward, she said, she and her family “read psalms.”


Isabel Kershner reported from Kiryat Malachi, Israel, and Fares Akram from Gaza. Reporting was contributed by Rina Castelnuovo from Kiryat Malachi; Mayy El Sheikh and David D. Kirkpatrick from Cairo; Gabby Sobelman from Jerusalem; Rick Gladstone from New York; and Alan Cowell from Paris.



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